Le cancer demeure l\u2019une des maladies les plus difficiles \u00e0 traiter. Malgr\u00e9 tous les efforts des m\u00e9decins, de nombreux patients cessent graduellement de r\u00e9agir aux traitements. R\u00e9sultat\u00a0: les cellules canc\u00e9reuses prolif\u00e8rent, de nouvelles tumeurs apparaissent et le patient finit par succomber \u00e0 la maladie. Cette r\u00e9sistance progressive de l\u2019organisme aux traitements, accompagn\u00e9e d\u2019une propagation de la maladie, d\u00e9coule d\u2019une surexpression des signaux contribuant \u00e0 la survie et la croissance des cellules canc\u00e9reuses. En per\u00e7ant le fonctionnement de ces signaux, on parviendra peut-\u00eatre \u00e0 les contrecarrer et \u00e0 se donner plus d\u2019outils pour le traitement du cancer. Un des signaux de survie des cellules est induit par un compos\u00e9 appel\u00e9 autotaxine. L\u2019autotaxine est mal r\u00e9gul\u00e9e et voit sa production augmenter sous l\u2019effet de nombreux traitements oncologiques, stimulant du coup la production de signaux de survie qui att\u00e9nuent l\u2019effet des traitements. On croit g\u00e9n\u00e9ralement qu\u2019il y a surexpression de l\u2019autotaxine \u00e0 l\u2019int\u00e9rieur m\u00eame des cellules canc\u00e9reuses. Or, mes recherches d\u00e9montrent que l\u2019expression de l\u2019autotaxine s\u2019observe surtout au niveau des cellules normales entourant les cellules canc\u00e9reuses. Les cellules normales r\u00e9agissent aux dommages caus\u00e9s par la chimioth\u00e9rapie et la radioth\u00e9rapie en augmentant leur production d\u2019autotaxine, d\u2019abord pour se prot\u00e9ger elles-m\u00eames, puis pour r\u00e9parer les dommages. En interagissant avec les cellules normales stimulant l\u2019expression d\u2019autotaxine qui entourent la tumeur, les cellules canc\u00e9reuses absorbent encore plus d\u2019autotaxine assurant leur survie. Nous sommes donc en pr\u00e9sence d\u2019un cercle vicieux qui diminue l\u2019efficacit\u00e9 des traitements. Mon but est de comprendre les interactions entre les cellules normales et les cellules canc\u00e9reuses formant une tumeur maligne. J\u2019esp\u00e8re d\u00e9couvrir des moyens de pr\u00e9venir la production d\u2019autotaxine pour ainsi accro\u00eetre l\u2019efficacit\u00e9 des traitements contre le cancer.<\/p>\n
Que signifie pour vous \u00eatre laur\u00e9at d’une bourse Killam?<\/strong><\/u> Qu\u2019en avez-vous retir\u00e9?<\/strong><\/u> Pourquoi avoir choisi l\u2019Universit\u00e9 de l\u2019Alberta?<\/strong><\/u> Malgr\u00e9 tous les efforts des m\u00e9decins, de nombreux patients atteitns d’un cancer cessent graduellement de r\u00e9agir aux traitements. <\/p>\n","protected":false},"featured_media":2594,"template":"","meta":{"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_links_to":"","_links_to_target":""},"categories":[116],"tags":[82],"class_list":["post-3002","scholars","type-scholars","status-publish","has-post-thumbnail","hentry","category-universite-dalberta","tag-medecine"],"featured_image_urls_v2":{"full":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2020\/07\/BeneschWEB.jpg",712,447,false],"thumbnail":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2020\/07\/BeneschWEB-150x150.jpg",150,150,true],"medium":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2020\/07\/BeneschWEB-300x188.jpg",300,188,true],"medium_large":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2020\/07\/BeneschWEB.jpg",712,447,false],"large":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2020\/07\/BeneschWEB.jpg",712,447,false],"1536x1536":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2020\/07\/BeneschWEB.jpg",712,447,false],"2048x2048":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2020\/07\/BeneschWEB.jpg",712,447,false],"small-square":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2020\/07\/BeneschWEB-217x217.jpg",217,217,true],"square-large":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2020\/07\/BeneschWEB-500x447.jpg",500,447,true]},"post_excerpt_stackable_v2":"
\nJ\u2019ai commenc\u00e9 mes \u00e9tudes en m\u00e9decine \u00e0 l\u2019Universit\u00e9 de l\u2019Alberta gr\u00e2ce \u00e0 une bourse d\u2019\u00e9tudes sup\u00e9rieures Vanier financ\u00e9e par le gouvernement du Canada. La bourse Killam reconna\u00eet l\u2019incidence et l\u2019utilit\u00e9 de mes recherches \u00e0 mesure qu\u2019elles progressent.<\/p>\n
\nLes fonds provenant d\u2019organismes comme les Fiducies Killam me permettent de me concentrer sur mes recherches et facilitent \u00e9norm\u00e9ment mes d\u00e9placements \u00e0 l\u2019\u00e9tranger, o\u00f9 je peux communiquer mes connaissances et recueillir de pr\u00e9cieux enseignements aupr\u00e8s de collaborateurs pour approfondir mes recherches.<\/p>\n
\nJ\u2019ai choisi l\u2019Universit\u00e9 de l\u2019Alberta afin de pouvoir travailler avec certains des meilleurs sp\u00e9cialistes dans mon domaine. Des cliniciens et des sp\u00e9cialistes des sciences fondamentales y supervisent mon travail, ce qui permet de v\u00e9rifier rapidement sur des patients certaines de mes constatations et de proc\u00e9der \u00e9ventuellement \u00e0 des essais cliniques.<\/p>\n","protected":false},"excerpt":{"rendered":"