{"id":6593,"date":"2023-03-15T10:00:00","date_gmt":"2023-03-15T10:00:00","guid":{"rendered":"https:\/\/killamlaureates.ca\/?post_type=scholars&#038;p=6593"},"modified":"2024-07-05T01:42:20","modified_gmt":"2024-07-05T01:42:20","slug":"adam-shuhendler","status":"publish","type":"scholars","link":"https:\/\/killamlaureates.ca\/fr\/laureates\/adam-shuhendler\/","title":{"rendered":"Adam Shuhendler &#8211; Bourse Dorothy Killam 2023"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>Enzymes are the protein machinery necessary for life, but the inappropriate actions of enzymes, at the wrong time and\/or the wrong place, drive disease. Dr. Shuhendler hopes to pinpoint strategies to thwart this hijacking activity of cancer, opening new routes to therapies preventing its spread.<\/strong><\/p>\n<\/blockquote>\n\n<p class=\"wp-block-paragraph\">Enzymes are the protein machinery necessary for life, but the inappropriate actions of enzymes, at the wrong time and\/or the wrong place, drive disease. This is particularly true in cancer, where enzymes are hijacked and forced to do all sorts of inappropriate things towards assisting the cancer in growing and spreading. However, a hijacking paradox is emerging: that enzymes with seemingly opposing purposes, for example the building up and the tearing down of the glue that holds our tissues and organs together, can both be co-opted by cancer to help it thrive.<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n<p class=\"wp-block-paragraph\">Using a new chemical platform, Dr. Shuhendler and team will map the opposing activities of these enzymes in animal models of disease using Magnetic Resonance Imaging (or MRI). This approach will allow Dr. Shuhendler to understand the relationship of these opposing enzymes in time and space over different processes key to cancer progression (for example tumor growth and metastasis). By unravelling the paradox of oppositional enzyme hijacking, Dr. Shuhendler hopes to pinpoint strategies to thwart this hijacking activity of cancer, opening new routes to therapies preventing its spread.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Les enzymes constituent la machinerie prot\u00e9ique n\u00e9cessaire \u00e0 la vie, mais les actions inappropri\u00e9es des enzymes, au mauvais moment et\/ou au mauvais endroit, sont \u00e0 l\u2019origine de la maladie &#8211; et c&#8217;est particuli\u00e8rement vrai dans le cas du cancer,<\/p>\n","protected":false},"featured_media":6502,"template":"","meta":{"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_links_to":"","_links_to_target":""},"categories":[135],"tags":[238,47,28],"class_list":["post-6593","scholars","type-scholars","status-publish","has-post-thumbnail","hentry","category-en-vedette","tag-biologie-chimique","tag-chimie","tag-sciences-naturelles"],"featured_image_urls_v2":{"full":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2023\/03\/SHUHENDLER.jpg",474,455,false],"thumbnail":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2023\/03\/SHUHENDLER-150x150.jpg",150,150,true],"medium":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2023\/03\/SHUHENDLER-300x288.jpg",300,288,true],"medium_large":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2023\/03\/SHUHENDLER.jpg",474,455,false],"large":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2023\/03\/SHUHENDLER.jpg",474,455,false],"1536x1536":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2023\/03\/SHUHENDLER.jpg",474,455,false],"2048x2048":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2023\/03\/SHUHENDLER.jpg",474,455,false],"small-square":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2023\/03\/SHUHENDLER-217x217.jpg",217,217,true],"square-large":["https:\/\/killamlaureates.ca\/wp-content\/uploads\/2023\/03\/SHUHENDLER.jpg",474,455,false]},"post_excerpt_stackable_v2":"<p>Les enzymes constituent la machinerie prot\u00e9ique n\u00e9cessaire \u00e0 la vie, mais les actions inappropri\u00e9es des enzymes, au mauvais moment et\/ou au mauvais endroit, sont \u00e0 l\u2019origine de la maladie &#8211; et c&#8217;est particuli\u00e8rement vrai dans le cas du cancer,<\/p>\n","category_list_v2":"<a href=\"https:\/\/killamlaureates.ca\/fr\/category\/en-vedette\/\" rel=\"category tag\">Laur\u00e9ats en vedette<\/a>","author_info_v2":{"name":"","url":""},"comments_num_v2":"0 commentaire","yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Adam Shuhendler - Bourse Dorothy Killam 2023 - Killam Laureates<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/killamlaureates.ca\/fr\/laureates\/adam-shuhendler\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Adam Shuhendler - Bourse Dorothy Killam 2023 - Killam Laureates\" \/>\n<meta property=\"og:description\" content=\"Les enzymes constituent la machinerie prot\u00e9ique n\u00e9cessaire \u00e0 la vie, mais les actions inappropri\u00e9es des enzymes, au mauvais moment et\/ou au mauvais endroit, sont \u00e0 l\u2019origine de la maladie - et c&#039;est particuli\u00e8rement vrai dans le cas du cancer,\" \/>\n<meta property=\"og:url\" content=\"https:\/\/killamlaureates.ca\/fr\/laureates\/adam-shuhendler\/\" \/>\n<meta property=\"og:site_name\" content=\"Killam Laureates\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/KillamTrusts\/\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-05T01:42:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/killamlaureates.ca\/wp-content\/uploads\/2023\/03\/SHUHENDLER.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"474\" \/>\n\t<meta property=\"og:image:height\" content=\"455\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@killamtrusts\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/killamlaureates.ca\\\/fr\\\/laureates\\\/adam-shuhendler\\\/\",\"url\":\"https:\\\/\\\/killamlaureates.ca\\\/fr\\\/laureates\\\/adam-shuhendler\\\/\",\"name\":\"Adam Shuhendler - Bourse Dorothy Killam 2023 - Killam Laureates\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/killamlaureates.ca\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/killamlaureates.ca\\\/fr\\\/laureates\\\/adam-shuhendler\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/killamlaureates.ca\\\/fr\\\/laureates\\\/adam-shuhendler\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/killamlaureates.ca\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/SHUHENDLER.jpg\",\"datePublished\":\"2023-03-15T10:00:00+00:00\",\"dateModified\":\"2024-07-05T01:42:20+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/killamlaureates.ca\\\/fr\\\/laureates\\\/adam-shuhendler\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/killamlaureates.ca\\\/fr\\\/laureates\\\/adam-shuhendler\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/killamlaureates.ca\\\/fr\\\/laureates\\\/adam-shuhendler\\\/#primaryimage\",\"url\":\"https:\\\/\\\/killamlaureates.ca\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/SHUHENDLER.jpg\",\"contentUrl\":\"https:\\\/\\\/killamlaureates.ca\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/SHUHENDLER.jpg\",\"width\":474,\"height\":455},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/killamlaureates.ca\\\/fr\\\/laureates\\\/adam-shuhendler\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/killamlaureates.ca\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Adam Shuhendler &#8211; 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